Pearl Trilogy

Small animal in vivo imager. The most versatile option with NIR-Fluorescence and Bioluminiscence.

  • Multi-target imaging
  • Ultimate easy of use
  • Versatile instrument
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Descripción del Producto

Near-Infrared Fluorescent and Bioluminescent Small Animal Imaging System

Pearl Trilogy Imaging System is a small animal near-infrared fluorescent and bioluminescent optical imaging system. At the heart of the Pearl Trilogy is revolutionary FieldBrite™ Xi2 technology.

FieldBrite™ Xi2 technology:

FieldBrite Xi2 technology allows you to detect smaller and deeper targets accurately in a single acquisition, without having to worry about saturation.

Combined with intuitive, easy-to-use Image Studio™ Software, the Pearl Trilogy will quickly become the favorite system in any lab, regardless of experience level.

With FieldBrite Xi2 technology, it’s easier to capture images, normalize your data and analyze your data.

The Pearl Trilogy is an affordable optical imaging solution that delivers trusted data to researchers world-wide. You can perform small animal imaging using near-infrared fluorescence, and now, bioluminescence.

Using FieldBrite™ Xi2 technology, the Pearl Trilogy delivers clear and accurate data you can rely on to help move your research forward. Because you use the same camera settings for every image, visual representation of changes in target size are more accurate.

Uniform Illumination

Reproducibility is critical for your research. And because many of your studies will be performed longitudinally, changes seen must reflect the biological changes of your experiment, not the limitations of your optical system.

FieldBrite Xi2 gives uniform illumination across the entire imaging area for this exceptional reproducibility (CV <3%). The laser illumination is stable throughout the course of your study – meaning any changes you see are based upon true biological phenomena.

Exceptional Sensitivity

Animal tissue strongly absorbs visible light, which prevents the light from reaching deeper targets. In addition, animal tissue has high autofluorescence when imaged in visible wavelengths (</=650 nm) which leads to poor Signal/Noise ratios and poor limits of detection.

Your solution is to image in the near-infrared (NIR) imaging window (680 nm – 820 nm). FieldBrite Xi2 optics ensures deep penetration of the tissue and also ensures the very best S/N ratios for the very best sensitivity.

FieldBrite Xi2 technology ensures the Pearl® Trilogy is sensitive enough to detect the small or deep tumors in your animal that are not yet palpable, both subcutaneous and orthotopic. Less probe is needed, making your experiments more cost effective

Wide Dynamic range.

Dynamic range is critical in small animal imaging, because signal will vary by multiple logs between animals and/or across a longitudinal study with many animals. The 6-log dynamic range of FieldBrite Xi2 technology ensures the capture of pure data containing no saturation, allowing you to use the same camera settings for every image you acquire. Thanks to FieldBrite Xi2, you are now able to accurately and reliably compare and quantify c

Technical Specifications

Detector TypeCCD. Thermoelectrically cooled
700 nm ChannelExcitation 685nm, Emission 720nm
800 nm ChannelExcitation 785nm, Emission 820nm
Bioluminescent ChannelExcitation, NA, Emission 450nm - 640nm
White ChannelExcitation white, Emission, NA
DyesIRDye® 680RD, IRDye 700DX, IRDye 800RS,
IRDye 800CW, Alexa Fluor 680, Alexa Fluor 790, and Cy® 5.5
Resolution85, 170, or 255 micron
Image Display OptionsPseudocolor, grayscale, single color (red, green, or blue), or two colors with overlapping fluorescence displayed in a third color
CapacityOne animal, with linked Lookup tables for image normalization
Imaging Bed16.8 cm W x 12 cm D (6.6” W x 4.75” D). Vertical clearance to top of drawer is 3.8 cm (1.5”)
Field of View11.2 cm W x 8.4 cm D (4.4” W x 3.3” D) at surface of imaging bed
Imaging Bed Temperature Range32-42 °C
Gas AnesthesiaInlet and outlet ports flow anesthesia gas through a nose cone in the imaging drawer. A rotameter is included for flow rate control
Acquisition Speed500ms - 60 seconds
Size41 W x 41 D x 66 cm H (16” W x 16” D x 26” H). Depth with imaging drawer open is 63.5 cm (25”)
Weight23 kg (50 lb)

Accesories

  • BrightSiteTM Optical Imaging Agents
  • Pearl Imaging Bed. The Pearl Imaging Bed is compatible with the Pearl Imaging System and the Pearl Docking Station. Once inserted into either the Pearl Docking Station or Pearl Imager, the Imaging Bed will be supplied with both heat and anesthesia
  • Pearl Docking Station. The Docking Station is a stand-alone unit that provides heat and HEPA‑filtered anesthesia (Anesthesia System not included) to either the Pearl Imaging Bed or the Pearl Clean Box. The Docking Station footprint is small and fits into traditional laminar flow hoods, allowing the user to prepare and position the mouse for imaging.
  • Pearl Clean Box. The Pearl Clean Box is compatible with the Pearl Imaging System and the Pearl Docking Station. Once inserted into either the Pearl Docking Station or Pearl Imager, the Clean Box will be supplied with both heating and anesthesia. This unique imaging bed, unlike the standard imaging bed, allows immunocompromised mice to be transported from the docking station clean area to the Pearl Imager in a closed system in order to avoid exposure to outside elements.
  • SmartFlow Anesthesia System. There are five basic considerations when choosing a method of anesthesia. Reduce the likelihood of animal loss. Avoid interfering with research question. Minimize the stress to animals. Maintain a consistent plane of anesthesia through the duration of the procedure. Have a fast and safe recovery at the end of anesthesia
  • Pearl Imaging Cart. This heavy duty stainless steel Pearl Imaging Cart turns your optical imaging lab into a mobile workstation. Sturdy design with plenty of room to accommodate a wide variety of accessories.
  • Compound Injection Clip. The Compound Injection Clip is a versatile accessory that securely holds a syringe/catheter system (not included), allowing compounds to be injected while an animal is simultaneously being imaged. The Compound Injection Clip:Accommodates syringes with ODs: 0.22 – 0.3″. Attaches to the Pearl Imaging Bed for easy transfer from work area to instrument.
  • Organ Tray Base & Trays. The Organ Tray Base and Disposable Organ Trays allow researchers to conveniently image organs on an unheated surface. This prevents organs from being compromised during the imaging procedure.

Aplications

  • Fluorescent optical imaging is an excellent way to examine the biodistribution of cells or labeled targeting agents as they are cleared from and/or specifically retained in the animal.
  • In Vivo Imaging. Optical imaging is a fast, sensitive, and cost effective way to image and track molecules in small animals. There are two main types of optical imaging: bioluminescent and fluorescent imaging.
  • Receptor Targeting. Cell surface receptors can be targeted forin vivo imaging by injection of agents that bind specifically to the receptor.
  • Structural Imaging. Structural imaging is often employed to more precisely localize an area of disease. Near-infrared dyes, such as IRDye fluorophores, and carefully optimized hardware are critical for high-performance optical imaging.
  • Transporter Targeting. Cell surface transporters can be used as targets forin vivo imaging by injection of agents that bind specifically to the transporter.
  • Vascular/Lymphatic Imaging. Imaging of targeting agents in the vascular and lymphatic systems is a specialized type of biodistribution study.

Technical Resources

Brochure

In Vivo Imaging

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